What is PK Deficiency



Contact a committee member for details.


PK Deficiency was first found to be present in some Singapura Cats in the UK in May 2011


Pyruvate Kinase (PK) Deficiency is an inherited disease.


PK is an enzyme found within red blood cells, which enables them to produce energy to survive. If this enzyme is lacking the lifespan of the red blood cells significantly reduces which can cause anaemia.  The disease is inherited as an autosomnal recessive trait which means a cat can be carrying the defective gene without having any symptoms of the disease. Affected cats arise when two carrier cats are mated together.


There are three statuses for cats:

Normal (Means the cat is clear and does not have any recessive genes)

Carrier (Means the cat has one copy of the recessive gene)

Affected (Means the cat has inherited one copy of the recessive gene from each parent)


A reliable DNA test is now available by way of a blood test or Buccal (cheek) swab.


The University of Bristol (Langford Diagnostics), UC Davis and Pennsylvania University are authorised to carry out this test.



All breeding Sinagpura’s should be microchipped and tested.


Anyone purchasing a cat or kitten for breeding purposes should request evidence of it being PKDef normal. Breeders should be happy to show you their cats and kittens test results.


http://www.langfordvets.co.uk/lab_pkdsampling.htm will take you to Langford vets site where you can order swabs, download submission forms and get instructions on how to take a buccal swab.

The Singapura Cat Club UK is registered with Langford Veterinary Diagnostics and Members should use the club code to obtain a discount. Samples are generally tested on Tuesdays and it is possible to receive results via email on the following day.




THE SCC AGM due to be held on Sunday 14th of April has been cancelled due to unforseen circumstances

You will be notified of new date.